This Palace takes its name from Lady Bettina Testaferrata Dorell who once lived there. Cardinal Fabrizio Sciberras Testaferrata – the only Maltese citizen to be elected Cardinal – was born in this house.

Towards 1842 St Emily de Vialler lived in this place along with a congregation of nuns. In the 1800’s Palazzo Bettina was reputed to be haunted.